T-Lymphocytes Subsets in Patients with chronic hepatitis that showed autoimmune phenomenon

Abstract

This study included 7 patients with autoimmune chronic hepatitis that infected previously with HBV (AIH-HBV), and 16 healthy human as a control group. No significant difference in number and percentage of T- Lymphocyte (CD3+ Cells) in the peripheral blood of patients with AICH as compared with control group. In addition, no significant increase in the percentage and number of CD4+ cells (P < 0.001) was reported and no significant decrease in the number and percentage of CD8+ cells (P < 0.01) was observed. These finding was concomitant with increase in CD4+/CD8+ ratio as compared with healthy control. In present study, it can conclude that the collaboration activity of both cells (CD4+ and CD8+) plays the crucial role in severity of AIH-HBV.